Ameano MOTS-c: the mitochondrial peptide explained
Ameano MOTS-c is a 10mg vial of a peptide coded in mitochondrial DNA, which is unusual in itself. Here’s where it came from, what labs study it for, and the compounds it’s often paired with.
What is Ameano MOTS-c?
MOTS-c is a 16-amino-acid peptide. Most proteins are coded in the nucleus, but MOTS-c is coded by a short stretch of the mitochondrial 12S rRNA gene. Changhan Lee, Pinchas Cohen and colleagues at the University of Southern California described it in Cell Metabolism in 2015.
Ameano MOTS-c is the synthetic peptide, freeze-dried in a sealed vial at 99% purity or better and labeled with a batch number. It’s sold for laboratory research only.
Ameano MOTS-c price and packs
- MOTS-C 10mg: from $54
It comes as a single vial, a 5 pack that saves 10% or a 10 pack that saves 15%. MOTS-c studies often run for weeks, so the packs are worth a look if you know you’ll get through them.
How MOTS-c acts in the lab
Its main target looks like the folate cycle. That leads to a build-up of AICAR, which switches on AMPK, an enzyme that acts as the cell’s energy sensor. In mouse studies that improved glucose handling in muscle and protected against diet-induced weight gain. Under stress, MOTS-c can move into the nucleus and change which genes are switched on.
Levels in the blood fall with age in both mice and people, which is why it shows up in aging research too. Start reading with this PubMed search for MOTS-c.
MOTS-c and exercise research
A 2021 paper in Nature Communications from Joseph Reynolds and the same USC group found that MOTS-c levels in human skeletal muscle rose sharply after exercise. In older mice, giving MOTS-c improved running capacity and grip strength. That’s one reason it’s studied as an exercise mimetic, a compound that triggers some of the same signals as physical activity. Most of this is still mouse work, and human data is limited.
What labs pair with Ameano MOTS-c
- Buffered NAD+ 500mg: from $68
- Buffered NAD+ 250mg: from $44
- 5-Amino-1MQ 50mg: from $68
- SS-31 30mg (ยง-31): from $98
- Epitalon 10mg: from $38
NAD+ is the coenzyme that mitochondria run on. 5-Amino-1MQ blocks NNMT, an enzyme that uses up NAD+ building blocks. SS-31 targets the inner mitochondrial membrane, and Epitalon is a short peptide from aging research. All of them sit in our anti-aging peptides or weight loss peptides pages.
Storing and mixing MOTS-c
Reconstitute with a sterile liquid such as our research diluent solution. A 10mg vial with 2mL gives 5mg/mL. Keep sealed vials in the fridge, or the freezer for long storage, away from light. After mixing, keep it cold and use it within about 28 days. The COA is available on request: email us the batch number on your label.
Ameano MOTS-c FAQ
What is MOTS-c?
A 16-amino-acid peptide encoded in mitochondrial DNA, described in 2015. It’s studied in metabolism and aging research.
What strength is Ameano MOTS-c?
10mg per vial, as a single vial, a 5 pack or a 10 pack.
What is it often studied with?
NAD+, 5-Amino-1MQ and SS-31, which all relate to mitochondria or cell energy.
Is MOTS-c approved for human use?
No. Ameano MOTS-c is sold for laboratory research only.
Buy MOTS-C 10mg from Ameano Peptides
In stock as a 10mg vial, 99% pure, with up to 15% off on packs.
Ameano Peptides research products are sold for laboratory research use only. They are not for human or veterinary use and have not been evaluated by the FDA. Skin care and hair care products are cosmetics for external use.